Categories

• papers 26
• paper 26
• misc 2
• home 1
• team 19
• news 30
• outreach 11
• projects 7
• project 7

papers

• Environment by environment interactions (ExE) differ across genetic backgrounds (ExExG)
• Single-cell heterogeneity in ribosome content and the consequences for the growth laws
• Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs
• An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts
• Intra-FCY1: a novel system to identify mutations that cause protein misfolding
• Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch
• Best practices in microbial experimental evolution
• Dissecting genetic correlation and pleiotropy through a genetic cross
• Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes
• Constructive Neutral Evolution 20 Years Later
• Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
• Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping
• The complete genome sequence of the Staphylococcus bacteriophage Metroid
• Emerging frontiers in molecular evolution
• Why and how to study genetic changes with context-dependent effects
• Decanalizing thinking on genetic canalization
• Questioning buffering
• Selection transforms the landscape of genetic variation interacting with Hsp90
• Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast
• Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
• The details in the distributions: How and why to study variability
• Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
• The ecoresponsive genome of Daphnia pulex
• Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
• A Δ11 desaturase gene genealogy reveals two divergent allelic classes within the European corn borer
• Construction of a high-resolution linkage disequilibrium map to evaluate neural tube defect risk in an Irish population

paper

• Environment by environment interactions (ExE) differ across genetic backgrounds (ExExG)
• Single-cell heterogeneity in ribosome content and the consequences for the growth laws
• Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs
• An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts
• Intra-FCY1: a novel system to identify mutations that cause protein misfolding
• Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch
• Best practices in microbial experimental evolution
• Dissecting genetic correlation and pleiotropy through a genetic cross
• Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes
• Constructive Neutral Evolution 20 Years Later
• Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
• Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping
• The complete genome sequence of the Staphylococcus bacteriophage Metroid
• Emerging frontiers in molecular evolution
• Why and how to study genetic changes with context-dependent effects
• Decanalizing thinking on genetic canalization
• Questioning buffering
• Selection transforms the landscape of genetic variation interacting with Hsp90
• Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast
• Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
• The details in the distributions: How and why to study variability
• Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
• The ecoresponsive genome of Daphnia pulex
• Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
• A Δ11 desaturase gene genealogy reveals two divergent allelic classes within the European corn borer
• Construction of a high-resolution linkage disequilibrium map to evaluate neural tube defect risk in an Irish population

misc

• Measuring impacts of mutation
• About

home

• Measuring impacts of mutation

team

• Yuichi Eguchi
• Gaurav Bilolikar
• Sam Apodaca
• Daphne Newell
• Ashley Brown
• Isabella Valli-Doherty
• Isabella Samples
• Garett Maag
• Avery Fry
• Amy Diyya
• Alex Sastokas
• Parker Crossland
• Mohammad Donyavi
• Rachel Eder
• Natalie Quan
• Dylan Padilla
• Kara Schmidlin
• Leandra Brettner
• Kerry Geiler-Samerotte

news

• Alex presents at the SOLUR symposium
• Kara wins people's choice award
• KGS lab hosts incoming freshman
• Alex and Ashley receive awards
• Parker awarded Master's degree
• KGS Lab presents at TAGC
• Kerry opens session at TAGC
• Leandra shares work at TAGC
• KGS lab outreach is a success!
• Kara presents research on drug resistant mutants
• Kerry organizes SMBE Satellite meeting
• Alex named a SOLUR Scholar
• KGS lab attends Gordon Conference
• Rachel awarded Master's degree
• KGS lab teaches public about DNA barcodes
• Rachel talks at AZ BioSci
• Leandra talks at YEAST 2022
• Rachel wins first place
• Sam gives the first talk at PEQG
• Vita is born
• Natalie shows poster at ASM
• Kara presents in Germany
• Rachel defends honors thesis
• Daphne defends honors thesis
• Sam defends honors thesis
• Kerry wins a Sloan Fellowship
• eLife paper receives attention
• Evolution experiment has begun!
• Our first paper is out!
• Dante is born

outreach

• Ashley Brown
• Isabella Samples
• Katrina Liou
• Anuva Banwasi
• Grace Lam
• Alycia Cary
• Esther Cao
• Naomi Jecker-Eshel
• Iris Wang
• Margot Bellon
• Chelsea Ramjeawan

projects

• Research Overview
• Building genotype-phenotype maps of drug resistance
• Quantifying the context-dependent costs of misfolding
• Devloping high-throughput phenotyping technology
• Breaking the (growth) law
• Tracing mutations impacts through regulatory networks
• Predicting gene and environment interactions

project

• Research Overview
• Building genotype-phenotype maps of drug resistance
• Quantifying the context-dependent costs of misfolding
• Devloping high-throughput phenotyping technology
• Breaking the (growth) law
• Tracing mutations impacts through regulatory networks
• Predicting gene and environment interactions