Categories

papers

An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts
Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs across hundreds of fluconazole-resistant yeast strains
Intra-FCY1: a novel system to identify mutations that cause protein misfolding
Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch
Best practices in microbial experimental evolution
Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes
Constructive Neutral Evolution 20 Years Later
Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation
Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping
The complete genome sequence of the Staphylococcus bacteriophage Metroid
Emerging frontiers in molecular evolution
Why and how to study genetic changes with context-dependent effects
Decanalizing thinking on genetic canalization
Questioning buffering
Selection transforms the landscape of genetic variation interacting with Hsp90
Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast
Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates
The details in the distributions: How and why to study variability
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects
The ecoresponsive genome of Daphnia pulex
Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast
A Δ11 desaturase gene genealogy reveals two divergent allelic classes within the European corn borer
Construction of a high-resolution linkage disequilibrium map to evaluate neural tube defect risk in an Irish population

paper

misc

home

Measuring impacts of mutation

team

news

outreach

projects

project