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Kerry Geiler-Samerotte

Principal investigator

Kerry is an assistant professor in the Biodesign Center for Mechanisms of Evolution and the School of Life Sciences at Arizona State University.

Kerry earned a bachelor’s degree from Cornell University in 2004 in Ecology and Evolutionary Biology, advised by Rick Harrison. She became enamored with the idea that small changes at the molecular level could have meaningful impacts. From this moment on she studied ideas related to understanding the impacts of genetic changes on cells, organisms and populations.

Kerry earned her PhD from Harvard University in 2011 in Organismal and Evolutionary Biology, co-advised by Daniel Hartl and D. Allan Drummond. Kerry’s postdoctoral work was completed with Mark Siegal in the Center for Genomics and Systems Biology at New York University, as well as with Dmitri Petrov at Stanford University.

Kerry’s interest in research began under the mentorship of her high school teacher, Paul Lichtman. Inspired by his mission to bring a love of science to underrepresented students, Kerry organizes a ‘women in science training program’ for high schoolers. See the Outreach page to find out more.

KGS Lab Papers

An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts

Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs across hundreds of fluconazole-resistant yeast strains

Intra-FCY1: a novel system to identify mutations that cause protein misfolding

Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch

Best practices in microbial experimental evolution

Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes

Constructive Neutral Evolution 20 Years Later

Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping

The complete genome sequence of the Staphylococcus bacteriophage Metroid

Emerging frontiers in molecular evolution

Why and how to study genetic changes with context-dependent effects

Decanalizing thinking on genetic canalization

Questioning buffering

Selection transforms the landscape of genetic variation interacting with Hsp90

Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast

Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates

The details in the distributions: How and why to study variability

Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects

The ecoresponsive genome of Daphnia pulex

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast