Publications
An ultra high-throughput, massively multiplexable, single-cell RNA-seq platform in yeasts

Brettner et al. Yeast 2024

Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs across hundreds of fluconazole-resistant yeast strains

Schmidlin et al. bioRxiv 2023

Intra-FCY1: a novel system to identify mutations that cause protein misfolding

Quan & Eguchi et al. Frontiers in Genetics, 2023

Extreme sensitivity of fitness to environmental conditions; lessons from #1BigBatch

Kinsler et al. J. Mol. Evol. 2023

Best practices in microbial experimental evolution

Geiler-Samerotte & Lang J. Mol. Evol. 2023

Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes

Brettner et al. Curr. Op. Genet. Dev. 2022

Constructive Neutral Evolution 20 Years Later

Munoz-Gomez et al. J. Mol. Evol. 2021

Fitness variation across subtle environmental perturbations reveals local modularity and global pleiotropy of adaptation

Kinsler & Geiler-Samerotte et al. eLife 2020

Extent and context dependence of pleiotropy revealed by high-throughput single-cell phenotyping

Geiler-Samerotte et al. PLOS Biology 2020

The complete genome sequence of the Staphylococcus bacteriophage Metroid

Crane et al. G3 2020

Emerging frontiers in molecular evolution

Liberles et al. J. Mol. Evol. 2020

Why and how to study genetic changes with context-dependent effects

Eguchi et al. Curr. Op. Genet. Dev. 2019

Decanalizing thinking on genetic canalization

Geiler-Samerotte et al. Sem. Cell Dev. Biol. 2019

Questioning buffering

Geiler-Samerotte et al. Cell Systems 2016

Selection transforms the landscape of genetic variation interacting with Hsp90

Geiler-Samerotte et al. PLOS Biology 2016

Development of a comprehensive genotype-to-fitness map of adaptation-driving mutations in yeast

Venkataram et al. Cell 2016

Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates

Geiler-Samerotte et al. PLOS ONE 2013

The details in the distributions: How and why to study variability

Geiler-Samerotte et al. Curr. Opin. Biotechnol. 2013

Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects

Pangilinan et al. BMC Medical Genetics, 2012

The ecoresponsive genome of Daphnia pulex

Colbourne et al. Science, 2011

Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast

Geiler-Samerotte et al. PNAS 2011

A Δ11 desaturase gene genealogy reveals two divergent allelic classes within the European corn borer

Geiler and Harrison. BMC Evol. Biol. 2010

Construction of a high-resolution linkage disequilibrium map to evaluate neural tube defect risk in an Irish population

Pangilinan et al. Am Journal of Med Genet A, 2008