Our goal is to understand and predict the impact of mutations. To this end, we develop technology and experiments that precisely quantify the impact of mutations on yeast cell physiology and growth. Yeast cells have a lot in common with human cells but are easier to work with. We pay particular interest to cases where the impact of a mutation changes across genetic or environmental contexts. By shedding light on the effects of mutations, our research provides insights about evolutionary processes and disease.

Sam Apodaca sucessfully defended his undergraduate honors thesis on the evolution of drug resistance. Congratulations Sam!!

Posted 12 Apr 2021

The Sloan Research Fellowships seek to stimulate fundamental research by early-career scientists and scholars of outstanding promise.

Posted 16 Feb 2021

Our recent paper in eLife about building abstract genotype-phenotype-fitness maps has been summarized in an eLife digest.

Posted 02 Dec 2020

Kara and Sam have started 12 evolution experiments, each one follows a population of ~500,000 barcoded yeast cells as they evolve drug resistance. Follow us on twitter! #KGSlabEvolves

Posted 27 Oct 2020